三黄肾康丸治疗大鼠慢性肾衰的实验研究

摘要

目的：观察三黄肾康丸对腺嘌呤致大鼠慢性肾衰（CRF）的影响。方法：连续喂养0.75％腺嘌呤使Wister大鼠产生类似于人慢性肾衰的症状。2周后，治疗组大鼠每天用中药三黄肾康丸（12.0g/kg、6.0g/kg）灌胃，连续6周，并于第4、8周测定大鼠血尿素氮（BUN）、肌酐（Scr）、RBC、HGB、HCT及肾脏病理学检查。结果：三黄肾康丸明显改善大鼠肾衰的症状，与模型组大鼠比较，肾重量减轻（P<0.01），纤维化程度降低，肾组织内结晶沉积物减少。结论：三黄肾康丸对大鼠肾衰有明显治疗效果。%OBJECTIVE： To observe the effects of SHSK on chronic renalfailure(CRF)in rats induced by adenine.METHODS： A rat model of renal failure,induced by feeding fodder containing 0.75％ adenine,could manifest signs resembling those observed in man with CRF.After two weeks of adenine feeding,SHSK in a dose of 12.0g/(kg· d) or 6.0g/(kg· d) was given to the rats for six weeks.At the 4th and 8th weeks,the BUN,Scr,RBC,HGB and HCT were detected and the pathalogy of the kidney was examined.RESULTS： The results indicated that SHSK given orally could improve the signs in rats with CRF.In comparison with the untreated control group,the kidney weight was lightened(P<0.01),crystals in renal tissue decreased and the proliferation of fibroid tissue was alleviated.CONCLUSION： SHSK has a markedly therapeutic effect on renal failure in rats.