门冬胰岛素治疗初期妊娠期糖尿病45例

摘要

Objective To explore the efficacy and safety of insulin aspart in pregnant women with gestational diabetes mellitus ( GDM ) . Methods 90 cases of pregnant women with GDM delivered at the hospital were divided into two groups, 45 cases in each group. The control group was treated with biosynthetic human insulin while the observation group was given insulin aspart. The levels of glucose were compared before and after 2 h at breakfast, lunch and supper. Results Comparison of the two groups of pregnant women treated with insulin four weeks after fasting and finger tip 2 h postprandial blood glucose after 3 meal showed that the blood glucose 2 h after breakfast in the observation group was ( 5. 2 ± 1. 7 ) mmol/L, while the control group was ( 7. 4 ± 1. 6 ) mmol/L;after dinner, the 2 h glu-cose in the observation group was ( 6. 0 ± 1. 5 ) mmol/L, while the control group was ( 7. 7 ± 1. 3 ) mmol/L, the differences were statistically significant ( P ﹤ 0. 05 ); the amount of insulin, blood glucose and time difference of the two groups was not statistically significant ( P ﹥0. 05 ) . Conclusion The efficacy and safety of insulin aspart for pregnant women with gestational diabetes mellitus is reliable.%目的：观察门冬胰岛素(诺和锐)治疗初期妊娠期糖尿病的疗效及临床安全性。方法选取2012年5月至2013年5月收治的妊娠期糖尿病患者90例，按随机数字表法分为观察组和对照组，各45例。两组均给予糖尿病饮食及有氧运动锻炼，对照组给予生物合成胰岛素(诺和灵R）治疗，观察组给予门冬胰岛素(诺和锐）治疗。比较两组治疗4周后空腹及餐后2 h血糖，并比较血糖达标时间及胰岛素用量。结果治疗4周后，早餐后2h血糖观察组为(5.2±1.7)mmol／L，对照组为(7.4±1.6)mmol／L；晚餐后2h血糖观察组为(6.0±1.5) mmol／L，对照组为(7.7±1.3) mmol／L，两组比较差异有统计学意义（ P﹤0.05）；两组孕妇胰岛素用量、血糖达标时间等差异无统计学意义（ P﹥0.05）。结论诺和锐治疗初期妊娠期糖尿病患者安全、有效，值得临床推广。