参麦注射液对气阴两虚型脓毒症患者r肠屏障功能的保护作用

摘要

目的 观察参麦注射液对气阴两虚型脓毒症患者肠黏膜屏障功能的保护作用.方法 选取医院2015年1月至2016年12月收治的气阴两虚型脓毒症患者82例,随机分为基础治疗组(对照组)和参麦注射液治疗组(治疗组),各41例.分别于入住急救部当时、入住后3 d及7 d(D0,D3,D7)检测血清二胺氧化酶(DAO)、肠脂肪酸结合蛋白(IFABP)及D-乳酸(D-Lac)水平变化,并记录患者急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分变化.结果 两组治疗前APACHEⅡ评分及血浆DAO,IFABP,D-Lac水平比较,差异均无统计学意义(P>0.05);治疗后,两组患者上述指标均逐渐下降,治疗组APACHEⅡ评分在D3[(16.12±2.15)分比(18.65±2.17)分]、D7[(11.11±2.13)分比(14.33±2.87)分]时明显低于对照组(P 0. 05). After treatment,the above indicators in the two groups were significantly decreased,the APACHEⅡ scores of treatment group at D3 [ (16. 12 ± 2. 15)points vs. (18. 65 ± 2. 17)points ] ,D7 [ (11. 11 ± 2. 13)points vs. (14. 33 ± 2. 87)points ] were significantly lower than those of the control group (P < 0. 05),the plasma IFABP contents in the treatment group was significantly lower than those in the control group at D3 [(55. 11 ± 6. 24)ng/mL vs. (67. 32 ± 5. 87)ng/mL] and D7 [ (9. 37 ± 6. 45) ng/mL vs. (29. 77 ± 5. 39) ng/mL) ] (P < 0. 05),the content of plasma DAO [ (2. 76 ± 0. 75) U/mL vs. (5. 13 ± 1. 08) U/mL ] ,D-Lac [ (1. 10 ± 0. 75) mmol/L vs. (2. 43 ± 1. 17) mmol/L ] of the treatment group were significantly lower than those of the control group at D7 (P < 0. 05). Conclusion TCM of Supplementing Qi and nourishing Yin has a positive effect on improving intestinal barrier function in patients with gastrointestinal dysfunction caused by sepsis.