Objective To explore the clinical value of combined detection of serum calcitonin and cerebrospinal fluid in the differential diagnosis of intracranial infection. Methods Group selection choose December 2014 to 2015 December 154 pa-tients underwent brain surgery as the research object, according to patients whether the occurrence of infection, it is divided into control group (n = 89) (uninfected) and experimental group of 65 cases (infected), patients were observed, the statistics of the positive and negative predictive value, specificity and sensitivity. Results Group selection Compared with the control group, the serum of the patients in the experimental group, the CSF PCT level and temperature significantly higher, P <0.05. Glucose levels were significantly lower, P< 0.05.WBC count, neutrophil percentage has increased, but compared with the control group difference not significant. The specificity of cerebrospinal fluid PCT in the diagnosis of intracranial infec-tion was 62.3%. Sensitivity is 97.1%. Before treatment, the protein quantitation of two groups of patients, the white blood cell count and serum PCT targets exist significant difference, after treatment, protein and white blood cell count does not exist significant. Serum PCT level exist significant difference; indicators before and after treatment of virus group there is no difference, bacteria groups exist significant difference. Conclusion The use of combined detection of serum PCT and CSF PCT, regular inspection, has a high sensitivity and specificity, for predicting postoperative intracranial infection has very important practical significance, it is worth further promotion.%目的：探究血清降钙素原联合脑脊液常规检测在颅内感染鉴别诊断应用的临床价值。方法整群选择2014年12月—2015年12月该院行颅脑手术的154例患者为研究对象，依照患者术后是否发生感染，将其分成对照组89例(未感染)和实验组65例(已感染)，对患者的相关情况进行观察，统计出阳性和阴性预测值，特异性，灵敏性。结果和对照组相比，实验组患者的血清，脑脊液PCT和体温明显较高，P<0.05.葡糖水平显著偏低，P<0.05.WBC计数，中性粒细胞百分比有所上升，但与对照组相比差异不显著。脑脊液PCT对颅内感染诊断特异性为62.3%。敏感性为97.1%。治疗前，两组患者的蛋白定量，白细胞计数和血清PCT指标存在差异有统计学意义，治疗后，蛋白质和白细胞计数差异无统计学意义，PCT血清水平存在差异有统计学意义；病毒组的治疗前后指标差异无统计学意义，细菌组差异有统计学意义。结论使用血清PCT联合脑脊液PCT及常规检验联合检测，有着较高的敏感度和特异度，对于预测患者术后颅内感染情况具有非常重要的现实意义，值得进一步推广。
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