设计合成了6个1-乙酰基-3-(2-羟基-4,6二甲氧基苯基)-5-芳基-2-吡唑啉化合物4a～4f.测试了它们的紫外光谱和荧光光谱,研究了其对铜离子的选择性识别作用.结果表明,化合物4f作为铜离子荧光探针,受常见离子干扰较小,对于铜离子有着较高的选择性和较低的检出限.%Copper plays an important role in various physiologic processes. The design and synthesis of chem-osensors for copper ions has become a very active area of research. The synthetic Cu2+ selective fluoroiono-phores so far reported suffer from low sensitivity and, in general, higher concentrations of interfering metal ions disturb the selectivity towards Cu2+. Here we report the synthesis of six l-acetyl-3-(2-hydroxyl-4,6-dimethox-ylphenyl)-5-aryl-2-pyrazoline(4a-4f) and the studies of them as fluorescent sensors for Cu2+ ion. The structures of all the products were determined by IR, MS, 1H NMR and elemental analysis. Their UV and fluorescence spectra were measured. The influences of eight metal ions such as Cu2 + , Zn2 + , Ni2 + , Co2 + , Na+ , Al3 + , Cd2 + , Ca2 + and Mn2 + on their fluorescence properties were studied. Spectroscopic studies revealed that the compounds 4a-4f had rather strong affinity toward Cu +. The specificity of the probes 4f toward Cu2 + were determined. Nearly no fluorescence intensity changes were observed in emission spectra with Zn2+ , Ni2+ , Co2+ , Na+, Al3+ , Cd2+, Ca2+ and Mn2 + . However, under identical conditions, the results showed fluorescence quenching with Cu2 +. So we have developed an new fluorescent sensor 4f. It shows high sensitivity and selectivity toward Cu2+ in DMSO.
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