Synthesis,characterization and antimicrobial activities of some fluorine containing 2-(l-phenyl-3-aryl-lH-pyrazol-4-yl)-3-chlorochromones,2-(l-phenyl-3-aryl-lH-pyrazol-4-yl)chromones and 5-(l-phenyl-3-aryl-lH-pyrazol-4-yl)-3-(2-hyroxyphenyl)-4,5-dihy

摘要

Base catalyzed condensation of 1 with 2 gives compound 3 [1-(5-fluoro-2-hydroxyphenyl)-3-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-2-propen-l-one].On oxidative cyclization with DMSO-CuCl_2 3 gives 2-(l-phenyl-3-aryl-lH-pyrazol-4-yl)-3-chloro-6-fluoro-chromones 4.On cyclization with DMSO-I2,3 gives 2-(l-phenyl-3-aryl-1H-pyrazol-4-yl)- 6-fluorochromones 5.When 3 is heated with hydrazine in dioxane gives 6 [5-(l-phenyl-3-aryl-lH-pyrazol-4-yl)-3-(5-fluoro-2-hydroxyphenyl)-4,5-dihydropyrazo-lines.The products 3,4,5 and 6 are characterized by spectral and elemental analysis.Compounds 3,4 and 6 are tested for their antimicrobial activities.