In Vitro Simulation of Flow Diverter Induced Clotting in Aneurysms Using Rennet Activated Milk Flow

摘要

This methodology provides an accelerated means to quantify and compare the potential of different flow diverters to induce aneurysm thrombosis using a simple bench top setup. Devices with lower porosity (ii and iii) can occlude aneurysms faster. The clotting time was shortest with the highest pore density device (iii), but its initiation time (consequently, the overall filling time) was longer than that of device ii. Further experiments will study these differences as well as correlation of milk clotting times to blood clotting times based on rheometry.