Potential of Pharmacodynamic Interaction for Hospital Patients with Stroke: A Retrospective Study

摘要

Stroke is a functional brain disorder in the form of nerve paralysis (deficit neurologic) due to obstruction of blood flow to the brain. Based on the Basic health research (Riskesdas) in 2018, the prevalence of stroke in Indonesia increased from 7% (2013) to 10.9% (2018) so it is necessary to optimize therapy for patients. Stroke treatment therapy, in general, uses two or more drugs (polypharmacy) so that this is able to increase the potential for drug interactions in patients either pharmacokinetic or pharmacodynamic. This study was aimed to investigate the potential for pharmacodynamic drug interactions and management of drug interaction events on stroke patients with polypharmacy therapy in hospital. The method of this study was retrospective observational. Data were analyzed descriptively using Stockley's Drug Interaction, Drug Interaction Facts, www.drugs.com database, and Medscape Drug Interactions Checker. The sampling technique employed in this study was total sampling method. The findings revealed that potential drug interactions on stroke patients in the hospital were 61.40% (n = 27 samples). The most mechanism pattern was pharmacodynamic interaction between aspirin-amlodipine (13.8%) and the most severity was in moderate level (77.78%).