Cardiac troponin detection using silicon photonic biosensor for the accurate and timely diagnosis and prognosis of acute myocardial infarction

摘要

We report a silicon Mach-Zehnder interferometer biosensor with an integrated microfluidic sample handling for anaccurate and timely detection of cardiac troponin. The performance of the photonic biosensor was evaluated in terms ofsensitivity, selectivity and reproducibility following the international clinical guidelines for acute myocardial infarctionwith the obtention of a complete cardiac troponin point-of-care test. We demonstrated that this biosensor was able toselectively detect cardiac troponin within 10 minutes in the ng/mL-μg/mL range with high reproducibility, achieving alimit of detection as low as 3 ng/mL in a direct assay.