Protective effect of phenolic extract of Cyperus rotundus rhizomes on myocardial infarction induced by isoproterenol in female rats

摘要

Objective: To asses the protective effect of phenolic extract of cyperus rotundus rhizomes on biochemical in isoproterenol induced myocardial infraction. Methods: Myocardial infarction was induced in rats by intraperitoneally injection of isoproterenol (85mg/kg) for two consecutive days at an interval of 24 h. Rats were treated with phenolic extract of cyperus rotundus rhizomes at two doses (15mg/kg, 30 mg/kg) for period 21 days and isoproterenol was injected on the 21~(th) and 22~(th) day. At the end of experiment i.e. on the 23~(th) day biochemical changes were monitored from control and experimental groups. Results: ISO injected rats showed a significant increase in d-dimer levels. In addition, it also exhibited alteration in the levels of electrolytes (Na~+ and Cl~-). It also showed significant decrease in level of K . Pretreatment with phenolic extract of cyperus rotundus rhizomes significantly prevented the ISO induced alteration in biochemical changes. Conclusions: The present result shows that treatment with phenolic extract of cyperus rotundus rhizomes in ISO injected rats significantly attenuates induced myocardial infarction.