A Novel Flow Control Valve for POCT Chip based on Micro Rectangular Groove Array

摘要

A novel flow control valve for point-of-care testing (POCT) chip, a micro rectangular groove array structure with capillary force as driving force, was proposed in this paper for the purposes of flowing controllable, spontaneous filling, low cost, and biological compatibility. The chip comprises two PMMA-based plates made of hot-embossing. The base plate and cover plate are connected by hot-bonding after ultrasonic cleaning and plasma treatment. An experiment has been carried out with deionized water to verify the control performance of fluid flow time in POCT chip by this method. The result convincingly indicates that this novel flow control valve could realize the function of controlling fluid flow, which meets the required time need for biochemical reactions. Compared with the controlling time of other previous methods in the POCT chip, the design in this study could make it to approximately 193~205 seconds. Therefore, this work has a great potential and broad prospects of the application in POCT chip, such as the portable devices in the medical testing field.