Protective Effects of Polysaccharides from Radix Astragali Against Alloxan-induced Oxidative Stress in Diabetic Mice

摘要

Oxidative stress has been proposed as an important pathogenic factor in diabetic wound complications. This study investigated the effect of polysaccharides from Radix Astragali (RAP) on alloxan-induced oxidative stress in diabetic mice. Diabetic mice were randomly divided into five groups: diabetic control, positive drug control, low, moderate, and high-dose RAP treated group. Meanwhile, normal mice were used as the control. RAP treated group received different doses of RAP (100, 200, and 400 mg/kg) via oral gavage once a day for 4 weeks. The effects of RAP on blood glucose, main antioxidant enzymes and malonaldehyde (MDA) were investigated. The results showed that RAP significantly increased superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) levels in liver and kidney, while decreasing blood glucose levels and MDA levels in liver and kidney in mice. These findings demonstrate that RAP possesses hypoglycemic and protective effect on alloxan-induced oxidative stress in diabetic mice.