Lipase Catalyzed Synthesis of High Optical Purity (S) - Naproxen Starch Ester

摘要

The high optical purity naproxen starch ester has been synthesized by Candida rugosa lipase (CRL) in isooctane. The starch was treated with Urea/NaOH/H_2O solution at low temperature to improve its chemical reactivity. Under the reaction condition that the ratio of racemic naproxen methyl ester to activation corn starch was 1:1, the amount of CRL was 10%(w/w), the reaction temperature was 65°C, the stirred speed was 100r/min, and the reaction time was 144 hours. The conversion of acemic naproxen methyl ester was 8.01% and the enantiomeric excess of the product (eep) was high to 96.01%. The production could be used as prodrug.