Activity of C-Reactive Protein, IL-6 and TNF-alpha in obese young people and its association with lipid profile.

摘要

Obesity (OB) has been defined as inflammatory state. The adipose tissue produce hormones and proinflammatory cytokines such as IL-6 and TNF-alpha, those stimulate the production C-reactive protein (CRP). We assessed 47 younger divided into two groups: OB and controls (C). Triglycerides and HDL were measured in serum. CRP was measured by immunoassay, IL- 6 and TNF-alpha by ELISA. We found statistically significant difference in triglycerides concentration HDL and IL-6. A discrete increase in TNF-alpha concentration in OB was observed. Moreover, IL-6 showed a direct correlation with BMI, CRP and triglycerides between obese and control group. We find high levels of triglycerides and decrease of HDL in the OB group suggest that the obesity is an inflammatory state and increase an irregular immune response.