Inactivation studies on Japanese Encephalitis Virus Vaccine using Design of Experiments

摘要

Japanese Encephalitis (JE) is a disease primarily dominant in South East Asia, caused by the Japanese Encephalitis virus (JEV, a Flavivirus, Figure 1). It is responsible for an estimated 50,000 cases of the disease every year, of which around 10,000 are fatal and approximately 15,000 result in long term neurological sequelae (WHO 2006).