Rational design of insect cell-based vaccine production =Bridging metabolomics with mathematical tools to study virus-host interactions

摘要

The increasing demand of baculovirus- based biopharmaceuticals raises the interest in developing high-titer production processes. Baculovirus infection boosts the host biosynthetic activity towards the production of viral components and the recombinant protein of interest, hyper-productive phenotypes being the result of a successful adaptation of the cellular network to that scenario. Thus, the comprehensive knowledge of the host cell metabolism, mainly in the post-infection phase, can provide clues on the metabolic adaptations that occur and, ultimately, aid bioprocess engineers in developing rational and targeted optimization strategies.