The use of a simple and small array to detect molecular interactions has several benefits such as the use of small analyte volumes, the ability to perform parallel screening of multiple interactions, and the ability to provide rapid response read-outs. Recently, transmission surface plasmon resonance (TSPR)-based nanosensors are developed to complement the existing SPR sensors. Similar to SPR spectroscopy, the sensing mechanism of TSPR spectroscopy is based on the measurement of small changes in plasmon resonance that occur in response to analyte binding at or near the surface of a noble metal. This TSPR nanosensor arrays have been prepared by Van Duyne’s nanosphere lithography or Rubinstein’s vacuum sputtering deposition.
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