NCL Diagnostic Algorithms

摘要

Two diagnostic algorithms, A and B are given. Algorithm A is for use in those cases where the first presenting clinical feature is visual failure and the main differential diagnoses are juvenile onset NCL, with typical or atypical ultrastructural features, and one of the variant late infantile NCLs. Algorithm B is for use in those cases presenting with other neurological problems between the ages of 1 and 7 years. The most frequently encountered diagnoses will be infantile and variant late infantile NCLs in Finland, and classic and variant late infantile NCLs in the rest of Europe. The diagnoses of Northern Epilepsy (CLN8) and congenital NCL are not considered here.