Simulation and analysis of dynamic brain PET images

摘要

We have developed a software package which combines the simulation and analysis of dynamic brain images acquired by positron emission tomography. In the spatial domain, standard digitized phantoms are used to create spatial maps which represent various structures in the brain. In the temporal domain, kinetic models are used to simulate the dynamics at the pixel level for each time-activity curve. Physical characteristics such as spatial resolution and noise are then modeled on individual image frames. This software has been used in the case of $LB@18F$RB@fluorodeoxyglucose studies to produce realistic simulations which were further analyzed to confirm previous findings based on real clinical data.