Smoking-Related Low HDL-C Level and Regression of Coronary Atherosclerosis during Statin Therapy (from the JAPAN-ACS study)

摘要

This study aimed to evaluate the influence of smoking and various lipid parameters on coronary plaque volume (PV) regression during statin therapy. We divided 252 patients with acute coronary syndrome (ACS) into two groups (nonsmok-ers or smokers). PV determined by intravascular ultrasound (IVUS) was measured at baseline and after 8-12 months of statin therapy. At baseline, age at ACS onset was younger in smokers than nonsmokers. Percent change in PV during statin therapy was equally reduced in nonsmokers and smokers. In smokers, low HDL-C (<40mg/ dL) group was weaker in regression of PV compared with high HDL-C (>40mg/dL) group. These effects were not observed in nonsmokers. In conclusions, Physicians should evaluate both HDL-C level and smoking status when starting statin therapy for ACS patients.