Comparison of solid phase micro-extraction headspace GC/FID and headspace GC/MSD for analysis of aromatic solvents in urine

摘要

Detection limit of toluene by SPME HS GC/FID was 6.8 μg/L, which enabled micro-scale analysis of organic solvent in urine. Linear range of each organic solvent was 10-400 μg/L, with fair correlation constant from 0.992 to 0.999. The detection sensitivity was 4 times better than HS GC/MSD(SIM mode). Accuracy was confirmed using commercial reference material containing 200 mg/L organic solvent, with about 90% accuracy. Toluene in urine was detected from 45 samples from workplace in the range of 20 - 324 μg/L. The data produced by SPME HS GC/FID method showed good relationship with hippuric acid in urine by GC/FID method. Analytical method for micro analysis of organic solvent in urine was investigated and showed good sensitivity and linearity for biological monitoring of organic solvent.