LC-MS and LC-MS/MS Study of Heparan Sulfate Oligosaccharides Processed by Human Sulf-2

机译：LC-MS和LC-MS / MS / MS研究人SULF-2处理的硫酸乙酰肝硫酸盐寡糖

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HSulf-2 acts preferentially on highly sulfated dp6-8 with 0-1 acetate group. The average sulfation degree decreased more for dp6-8 with zero acetate than for those with one acetate group upon HSulf-2 treatment. Only a subset of HS dp6 and dp8 are affected by HSulf-2 for a given composition. LC-tandem MS can reveal the difference of isomeric distribution changes by HSulf-2.

机译：HSULF-2优先用0-1乙酸盐基团的高硫酸化DP6-8作用。对于零醋酸盐的DP6-8，平均硫化度比对于HSULF-2治疗时的醋酸盐基团的平均硫化度降低。对于给定的组合物，仅受HS DP6和DP8的子集受HSULF-2的影响。 LC-TANDEM MS可以通过HSULF-2揭示异构分布变化的差异。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2011年||共1页
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Yu Huang; Xiaofeng Shi; Joseph Zaia;
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中图分类 TB994.5-53;
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LC-MS and LC-MS/MS Study of Heparan Sulfate Oligosaccharides Processed by Human Sulf-2

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