Method Development for the Determination of Lamotrigine, Topiramate, Phenytoin, and Phenobarbital in Human Serum Using Isotope-Dilution Liquid Chromatography-Mass Spectrometry

摘要

This reference measurement procedure for LTG, TPM, PHT, and PHB in serum, which demonstrates good accuracy and precision can be used to provide an accuracy base to which routine methods for AEDs can be compared and that will serve as a standard of higher order for measurement traceability.