Hemangiosarcoma is perhaps the most aggressive vascular tumor diagnosed in dogs. Although systematic surveys are not available to obtain accurate estimates of risk and incidence in companion animals, hemangiosarcoma appears to be relatively common indogs, unlike it's counterpart in humans, commonly called angiosarcoma, which is vanishingly rare (<0.01% of human tumors). Reports of canine hemangiosarcoma are traceable to the early 1960's in the current medical literature. By the mid 1970's, Priesterhad recognized that hemangiosarcoma of the liver occurred 25 to 100 times more frequently in dogs than in humans,1 and by the late 1970's, various investigators noted a breed predilection in German Shepherd Dogs in Europe.2'3The breed predilection for hemangiosarcoma was confirmed and extended through various retrospective studies in the US in the 1980's and 1990's.4"6 Seminal work from Priester and McKay published as an NCI monograph in 1980 provided the first reasonable estimate for the occurrence of hemangiosarcoma in domestic dogs in North America.7 The data were obtained from the Veterinary Medical Data Program (VMDP), consisting of 15 veterinary schools in the U.S. and Canada between 1964 and 1977. Priester and McKayclassified angiosarcomas in the category of hematopoietic neoplasms, reporting 165 cases. To put this number in context, the database included approximately 1.6 million records, and >41,500 had a recorded "tumor" event, although most "tumors" were benign. There were almost 10 times more lymphomas than splenic hemangiosarcomas in the VDMP, but about the same number of leukemias; splenic hemangiosarcomas accounted for -0.3% of all benign and malignant tumors. Several of the common breeds we now associatewith this disease, including Boxers and Golden Retrievers, were already overrepresented in the affected population of this systematic survey. Notably, Priester and McKay reported no significant differences in risk between male, female, or neutered animals. Arguably, the larger prevalence of sexually intact animals in that era might provide more accurate numbers to assess the potential effect of neutering on a dog's risk to develop this disease.
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机译：升血管瘤可能是诊断犬诊断的最具侵略性的血管肿瘤。虽然系统的调查无法获得伴侣动物的准确估算风险和发病率，但致血管瘤似乎是相对普遍的印刷品，与其在人类的对应物，通常称为angiosarcoma，这缺乏罕见的罕见（<0.01％的人类肿瘤）。犬升血管瘤的报道可追溯到1960年代早期的医学文献。在1970年代中期，Priesterhad认识到肝脏的血管瘤比人类在血液中发生25至100倍，并在1970年代后期，各种调查员注意到欧洲德国牧羊犬的一种品种偏好.2'3品种偏好对于致血管达达尔通过美国于1980年代和1990年代的各种回顾性研究得到了确认和延长了Priester and Mckay的6个开创性工作，于1980年为NCI专着发布的NCI专着，为北方国内犬出现的血管核瘤发生的第一个合理估算美国.7数据是从兽医资料计划（VMDP）获得的，由美国和1977年之间的15个兽医学校组成，1964年至1977年之间。在造血肿瘤类别中Priester和McKayclasified Agiosarcomas，报告165例。把这个上下文中的数量，数据库包括大约160万条记录，> 41,500有一个记录的“肿瘤”事件，虽然大多数“肿瘤“是良性的。淋巴瘤在VDMP中的脾血管瘤几乎存在近10倍，但大约相同的白血病;脾血管瘤占-0.3％的良性和恶性肿瘤。我们现在对这种疾病相关的几种常见品种，包括拳击手和金色的猎犬，在受影响的这种系统调查人口中已经过分了。值得注意的是，Priester和Mckay报告雄性，女性或绝育的动物之间没有显着差异。可以说，在该时代的性质完善的动物的流行率较大，可以提供更准确的数量来评估中间对狗的风险发展这种疾病的潜在影响。
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