Prognostic Factors for the Presence of the Methastasis in Lymph Nodes and Organs in Bulgarien Patients with Colorectal Carcinoma

摘要

Colorectal carcinoma (CRC) is the third most common malignant tumor among all organ localizations and second most common cause of mortality in developed countries. CRC is divided into three main histological types according to the WHO classification: carcinomas, neuroendocrine neoplasms and mesenchymal tumors. The most common type is the adenocarcinoma and it is the subject of our study. In the present study, logistic regression was used to model the occurrence of metastasis in lymph nodes and organs, depending on anti-BRAF(V600E) antibody, anti-APC antibody, anti- MSH2 antibody, anti-SMAD antibody and anti-P53 antibodyin order to identify the statistically significant ones. The obtained models allow us to estimate the predicted probability of the occurrence of this complication by setting the individual values for the intensity and expression of the antibodies. The models were based on experimental data from histologically verified colorectal adenocarcinomas in a study of biopsy materials in the Clinic of General and Clinical Pathology, University Hospital "St. Marina" - Varna, Bulgaria.