Identification of emerging pharmaceutical pollutants and human metabolites in urban wastewater treatment plants using effect-directed analysis

摘要

In this work, WWTP samples were shown to present estrogenic and androgenic activities and a part of these activities could be explained by natural steroids detected by target chemical analysis. Considering the thousands of compounds present in crude extracts, EDA allowed to simplify samples focusing only on the active fractions and so to simplify the EDCs identification process. This approach combined to LC-QTOF has currently allowed establishing a list of non-target candidate compounds that could explain observed biological activities.