α-Naphtyl Substituted Pirinixic Acid Derivatives as Potent Selective Agonists of the Peroxisome Proliferator-Activated Receptor Gamma

摘要

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, playing an essential role in energy homeostasis. Agonists of PPARs are important drugs for dyslipidemia and type 2 diabetes mellitus Bezafibrate, Fenofibrate and Rosiglitazone are already available for therapy, but they show adverse effects like liver toxicity, myopathy or rhabdomyolysis. Therefore new PPAR agonists with improved pharmacological profiles are still required.