Pretreatment Serum Testosterone Level Can Predict Pathological Stage in Localized Prostate Cancer Patients Treated with Radical Prostatectomy

摘要

Objective: The present study was conducted to evaluate the clinical significance of pretreatment serum testosterone (T) level in patients with clinically localized prostate cancer.Materials and methods: We investigated clinical and pathological factors such as pretreatment serum T level, age, pretreatment PSA or pathological Gleason score concerning the association with pathological stage and biochemical recurrence.Results: The mean pretreatment T level was significantly lower in patients with non organ-confined prostate cancer than in patients with organ-confined cancer. When the patients were divided into high and low T level groups, pretreatment T levels were not significantly associated with PSA recurrence rates.Conclusions: A lower pretreatment T level appears to be predictive of extraprostatic disease in patients with localized prostate cancer.