The Effects of Partial Fat Acid Inhibitor Trimetazidine on Global and Regional Diastolic Left Ventricle Function in patients with Hibernating Myocardium

摘要

The pathophysiological condition of myocardium after infarction is extremely heterogeneous. There are a few data about the contribution of segments with different ischemic conditions, especially with hibernation, in the setting of diastolic- dysfunction. Also, there is no adequate drug treatment of diastolic heart failure, especially ischemia-induced. A new class of treatment of heart failure - partial fatty acid oxidation inhibitors and among them 3 -ketoacyl-coenzyme A thiolase (3-KAT) inhibitor, trimetazidine are now available [1]. This orally active metabolic agent has been shown to improve both global and regional systolic function [2J with effectiveness of restoration of hibernating myocardium function comparable with revascularisation [3]. But at present it is not evident that trimetazidine is able to improve global and regional diastolic function. We tried to prove the beneficial effects of partial fat acid inhibitor trimetazidine on left ventricle (LV) global and regional systolic and diastolic function in patients with hibernating myocardium.