Chemistry and antioxidative factors in rosemary and sage

摘要

Rosemary and sage are common spices used in food. In our recent search of cancer chemopreventive agents from spices, the alcohol extracts of rosemary and sage showed strong antumorigcnic activities. Rosemary and sage extracts contain active antioxidative factors such as phenolic diterpenes, flavonoids and phenolic acids. Here we discuss chromato-graphic methods used to separate and purify compounds from these spices and MS and NMR spectromelry to identify the isolated compounds. Several new compounds isolated from sage were determined to be 6-O-cafreoyl-beta-D-fructofuranosyl-(2 -> 1)-beta-glucopyranoside, 1-O-caffeoyl-beta-D-apiofuranosyl-(l -> 6)-beta-D-glucopyranoside, 1-O-p-hydroxybenzoyl-beta-D-apiofuranosyl-(1 -> 6)-beta-D-glucopyranoside, 1-O-(3-methyl-2,3,4-trihydroxybutyl)-6-O-feruloyl-beta-D-glucopyranoside, 4-hydroxyacetophenone 4-O-[5-O-(3,5-dimelhoxy-4-hydroxybenzoyl)-beta-D-apiofrunosyl]-(1 -> 2)-beta-D-glucopyranoside and 1-O-[2-hydroxy-5-(2-hydroxyethyl)phenyl]-6-O-trans-caffeoyl-beta-D-glucopyranoside.