Immunostimulation Effect of the Jellyfish Collagen

摘要

The jellyfish extract enhanced IgM production of human hybridoma HB4C5 cells 34-fold. IgM and IgG production of human peripheral blood lymphocytes (hPBL) were also accelerated 2.8- and 1.4-fold, respectively. Moreover, IFN-y and TNF-alpha production by hPBL were stimulated 100- and 17-fold, respectively. Collagenase treatment inactivated the immunostimulation activity of the jellyfish extract. In addition, purified collagen from bovine Achilles' tendon accelerated IgM production of hybridoma cells. These facts mean that collagen has immunostimulation effect, and the active substance in jellyfish extract is collagen. As the result of the investigation about the mode of action, collagen stimulates both transcription and translation activities to enhance Ig production.