DOWNREGULATION OF alpha_5beta_1 INTEGRIN EXPRESSION DURING NEURONAL DIFFERENTIATION IN NEURAL STEM CELLS

摘要

During neuronal differentiation, dynamic morphological and physiological changes found in neural stem cells imply the involvement of cell adhesion molecules. Integrins, which are major family of cell adhesion molecule play a central role in migration, proliferation and differentiation in various cells through extrinsic and intrinsic cellular signals. In this study, we indicated that integrin alpha_5beta1 are involved in neuronal differentiation in neural stem cells under the neurogeninl expression.