Molecular imprints as artificial antibodies - a new generation of chemical sensors

摘要

An improved generation of molecular hollows for analyte inclusion is offered by molecular imprinting.Synthesis of the layer is performed in presence of the analyte,which after it;s removal from the highly crosslinked matrix leaves behind cavities and diffusion pathways capable of it's reinclusion.The resulting layers show excellent mechanical and chemical stability and can be synthesized directly on a suitable transducer.Polycyclic aromatic hydrocarbons cna be selectively monitored in water down to a few ng/l by fluorescence or mass sensitive detection principles.The sensitivity of a layer cna be tuned by using different PAH's as temeplate molecules.Mass-senstive measurements in liquid phase show a high sensitivity both with QMB's and shear wave resonators,negligible effects were obained with non-imprinted polymers.Imprinting methods even enable global characteerization fo complex mixtures such as engine-oil.Imprinted polymeric layers yield mass effects that are caused by an extraction of ooil ocmponents characteristic for the degradation process.