Nir spectroscopy of film-coated tablets-fast and nondestructive evalaution of film coat uniformity and drug release kinetics

摘要

Film coating of tablets and pellets is commonly used to mask a bad taste of the drug, to improve chemical or physical stability of the dosage form and/or to control drug release kinetics. Since a uniform thickness, morphology and microstructure of the film coat are prerequisites to achieve these properties, 100