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Photo-mediated Ultrasound Therapy to Treat Retinal Neovascularization

机译:光介导的超声疗法治疗视网膜新生血管。

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This report describes a novel therapeutic technique called photo-mediated ultrasound therapy (PUT). PUT applies synchronized short pulse duration (nanosecond) laser and ultrasound burst on targeted tissue, offering high-precision localized treatment. PUT is based on controlled induction and promotion of micro-cavitation activity in the target tissue. PUT is able to safely and effectively treat retinal neovascularization in rabbits with persistent nonperfusion up to 4 weeks after PUT in the choroidal vasculature.Clinical Relevance— PUT can selectively remove retinal angiogenesis in clinically-relevant disease models in humansized eyes (rabbit) without damaging surrounding tissue.
机译:该报告介绍了一种称为光介超声治疗(PUT)的新型治疗技术。 PUT在目标组织上施加同步的短脉冲持续时间(纳秒)激光和超声脉冲,可提供高精度的局部治疗。 PUT基于目标组织中微空化活性的受控诱导和促进。 PUT能够安全有效地治疗脉络膜脉管系统中进行PUT后持续不灌流长达4周的兔子的视网膜新血管形成。临床相关性-PUT可以选择性地去除人眼(兔子)临床相关疾病模型中的视网膜血管生成,而不会损害周围环境组织。

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