紫外光A核黄素介导角膜交联治疗感染性角膜炎

摘要

角膜胶原交联（ CXL）技术是一种治疗圆锥角膜、准分子激光术后角膜扩张、难治性角膜溃疡、角膜炎等角膜疾病的有效方法。它通过紫外光A和感光剂核黄素，介导角膜基质内胶原纤维相互交联而提高角膜机械硬度和角膜基质的生物力学稳定性，从而阻止圆锥角膜等角膜扩张性疾病和难治性角膜炎等的发展。本文就紫外光A核黄素介导角膜交联术治疗感染性角膜炎的基本原理、实验和临床研究现状及其相关安全性等问题进行综述。%Corneal collagen cross-linking ( CXL) through UVA-riboflavin photochemistry has been shown to be an effective treatment for keratoconus , keratectasias and refractory infectious corneal ulcer .CXL increases corneal rigidity , im-proves mechanical and biochemical stability of the stroma , and prevents the progression of corneal expansion and corneal ul-cer.The purpose of this paper is to review basic principles , existing evidences from laboratory and clinical studies , and the safety of corneal cross-linking in the treatment of infectious keratitis .