TiO_2 nano-dimensioned surfaces modulate host inflammation via mediating macrophage M1/M2 polarization

摘要

Small scale of nano-dimensioned TiO2 surface(NT5,30nm in diameter) help to maintain the static status of macrophage and to induce macrophage polarizing to anti-inflammatory M2 phenotype, which is benefit to inflammation resolution and bone regeneration. Manipulating nano-scales of surface topography can effectively regulate host innate inflammation and probably be a new strategy to improve performance of implanted biomaterials. However, additional research is still need to clarify the mechanism of surface-induced intracellular signal pathway.