Pharmacoscintigraphic Evaluation of Polysorbate80 Coated Chitosan Nanoparticles for Brain Targeting

摘要

The concentration of 99mTc labeled chitosannanoparticles in brain was increased to nearly fivefolds when coated with polysorbate80 (1% w/w) ascompared to the uncoated 99mTc labeled chitosannanoparticles. The optimal concentration ofpolysorbate80 in chitosan for the delivery ofnanoparticles to brain was found to be 1% w/w.Because of partial surface hydrophobicity renderedto the chitosan nanoparticles on coating withpolysorbate80, blood kinetics data showed rapidclearance from blood in coated nanoparticles thanuncoated nanoparticles. These results were furthersupported by the gamma scintigrams of NewZealand rabbits, which showed that the 99mTclabeled chitosan nanoparticles when coated withpolysorbate80(1% w/w) had a greater uptake bybrain tissue as compared to the uncoated chitosannanoparticles. The results from present study showsthat chitosan nanoparticles coated withpolysorbate80 has a great potentiality as a drugdelivery carrier to the brain.