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METHOD FOR DETERMINING PREGNANCY STATE OF PREGNANT WOMAN

机译:确定孕妇妊娠状态的方法

摘要

A method for constructing a prediction model. The prediction model is used for predicting the pregnancy state of a pregnant woman. The method comprises: (1) constructing a training set and an optional test set, wherein the training set and the optional test set are composed of a plurality of pregnant women samples, and the pregnant women samples have known pregnancy states; (2) for each pregnant woman sample of the training set, determining a predetermined parameter of the pregnant woman sample, wherein the predetermined parameter comprises differentially expressed gene information of the pregnant woman sample, and the differentially expressed gene information is obtained by means of calculating sequencing information of fetal cell-free nucleic acids in peripheral blood of the pregnant woman sample; and (3) constructing a prediction model on the basis of the known pregnancy states and the predetermined parameter.
机译:一种构建预测模型的方法。该预测模型用于预测孕妇的妊娠状态。该方法包括:(1)构造训练集和可选测试集,其中训练集和可选测试集由多个孕妇样本组成,且孕妇样本具有已知的妊娠状态;(2) 对于训练集的每个孕妇样本,确定孕妇样本的预定参数,其中预定参数包括孕妇样本的差异表达基因信息,通过计算孕妇样本外周血中胎儿游离核酸的测序信息,获得差异表达的基因信息;以及(3)基于已知妊娠状态和预定参数构建预测模型。

著录项

  • 公开/公告号WO2022082436A1

    专利类型

  • 公开/公告日2022-04-28

    原文格式PDF

  • 申请/专利权人 BGI GENOMICS CO. LTD.;

    申请/专利号WO2020CN122214

  • 发明设计人 CHEN RUOYAN;XU JINJIN;JIN XIN;

    申请日2020-10-20

  • 分类号C12Q1/6809;C12Q1/6881;

  • 国家 CN

  • 入库时间 2022-08-25 00:47:52

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