MAGNETIC ULTRASOUND CONTRAST AGENT COMPOSITION, MAGNETIC ULTRASOUND CONTRAST AGENT, AND MAGNETIC MICROBUBBLE ULTRASOUND CONTRAST AGENT AND PREPARATION METHOD THEREFOR

摘要

A magnetic ultrasound contrast agent composition, a magnetic ultrasound contrast agent, and a magnetic microbubble ultrasound contrast agent and a preparation method therefor. The magnetic ultrasound contrast agent composition comprises a lipid, a surfactant, and a magnetic nanoparticle; the surfactant consists of a surfactant A and a surfactant B; the surfactant A is in a free state, and the surfactant B is in a bonding state and is modified on the surface of the magnetic nanoparticle; the HLB value of the surfactant A is greater than 8; and with respect to 1 mol of the lipid, the content of the surfactant A is 0.1-1 mol, the content of the surfactant B is 0.1-1 mol, and the content of the magnetic nanoparticle is 0.05-0.5 mol. The magnetic microbubble ultrasound contrast agent obtained from the magnetic ultrasound contrast agent composition has high stability and can meet requirements for in vivo cyclic targeted delivery, thereby achieving the local high-concentration targeted delivery of a medication.