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IncRNAs GADLOR 1 and 2 for use in treating and preventing cardiac remodelling
IncRNAs GADLOR 1 and 2 for use in treating and preventing cardiac remodelling
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机译:Incrnas Gadlor 1和2用于治疗和预防心脏重塑
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摘要
The present invention relates to a compound inhibiting the expression and/or the activity of a long non-coding RNA (lncRNA) selected from GADLOR 1 and GADLOR 2 for use in treating or preventing cardiac remodelling, wherein GADLOR 1 comprises or consists of a nucleic acid sequence selected from the group consisting of SEQ ID NOs 1 to 3 and sequences being at least 75% identical thereto, and GADLOR 2 comprises or consists of a nucleic acid sequence selected from the group consisting of SEQ ID NOs 4 to 6 and sequences being at least 75% identical thereto.
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机译:本发明涉及抑制选自Gadlor 1和Gadlor 2的长非编码RNA(LNCRNA)的表达和/或活性的化合物,用于治疗或预防心脏重塑,其中Gadlor 1包含或由核组成 选自SEQ ID NO 1至3的酸序列和至少75%相同的序列,并且Gadlor 2包括或由选自SEQ ID NO 4至6的核酸序列组成或由序列组成 至少75%相同。
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