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EXTRACELLULAR DOMAIN OF ALPHA SUBUNIT OF IGE FC RECEPTOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME AND METHOD FOR PRODUCING SAME
EXTRACELLULAR DOMAIN OF ALPHA SUBUNIT OF IGE FC RECEPTOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME AND METHOD FOR PRODUCING SAME
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机译:IgE Fc受体的α亚基的细胞外结构域,包含该方法的药物组合物和制备方法
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摘要
The present invention provides a polypeptide dimeric protein containing two monomers, each of which contains an extracellular domain (FcεRIa-ECD) of an alpha subunit of an IgE Fc receptor. The dimeric protein according to the present invention has advantages that an excellent binding ability to IgE is exhibited as compared with a conventional therapeutic agent containing an anti-IgE antibody, and less other side effects are exhibited due to lack of ADCC and CDC functions. Thus, the dimeric protein can be applied to a medical product for treating or preventing an IgE-mediated allergic disease.
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