Oncolytic recombinant newcastle disease virus contain PTEN gene constructed by based on the Newcastle disease virus for glioblastoma treatment and its composition

摘要

The present invention relates to an oncolytic virus for brain tumor treatment using a Newcastle disease virus vector-based PTEN (phosphatase and tensin homolog) gene insertion recombinant Newcastle disease virus, and a composition for brain tumor treatment using the same. The PTEN gene was included in Newcastle Disease Virus (NDV), which can be spread up to, and it was confirmed that the PTEN protein was expressed in cancer cells to treat brain tumors through apoptosis of brain tumor cells. Therefore, the present invention is a recombinant Newcastle disease virus containing a human PTEN protein gene that is infected with brain tumor cells and expresses normal PTEN protein to reduce clinical symptoms or induce partial or complete remission through brain tumor cell death or brain tumor tissue shrinkage. It relates to antiviral agents.