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ACE2-FC FUSION PROTEINS FOR SARS-COV-2 MITIGATION
ACE2-FC FUSION PROTEINS FOR SARS-COV-2 MITIGATION
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机译:用于SARS-COV-2缓解的ACE2-FC融合蛋白
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摘要
The present disclosure relates to recombinant fusion proteins comprising an extracellular domain of the human angiotensin-converting enzyme 2 (ACE2), optionally having altered amino acid residues that result in increased binding affinity for the S1 spike protein of SARS-CoV-2, linked to a human immunoglobulin Fc region, that can extend the protein half-life (T1/2) and/or the duration of action as a decoy receptor, and compositions and methods of use of these fusion proteins.
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