Soluble interleukin-7 receptor (sil7r) regulatory therapy to treat autoimmune disease and cancer

摘要

The present invention relates toContains compositions and methods for the treatment of autoimmune disorders or cancers in subjects requiring itHow toContains an effective amount of a composition containing an oligonucleotide that specifically binds to the complementary sequence of the interleukin 7 receptor (IL-7R) pre mRNA that affects splicing of exon 6, andSMIIncrease or decrease the content of exon 6 in IL-7R pre mRNAExpression of IL-7R soluble isoformRespectivelyReduce or increase.In certain embodiments, the oligonucleotide is an antisense oligonucleotide (ASO) or splice regulated antisense oligonucleotide (sm-aso).Selection diagram