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Soluble interleukin-7 receptor (sIL7R) modulating therapy to treat autoimmune diseases and cancer
Soluble interleukin-7 receptor (sIL7R) modulating therapy to treat autoimmune diseases and cancer
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机译:可溶性白细胞介素-7受体(SIL7R)调节治疗治疗自身免疫疾病和癌症
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摘要
The present invention includes compositions and methods for treating an autoimmune disorder or a cancer in a subject in need thereof, the method comprising: administering an effective amount of a composition comprising an oligonucleotide that specifically binds a complementary sequence of the Interleukin-7 receptor (IL7R) pre-mRNA that influences splicing of exon 6, wherein the SM-ASO increases or decreases inclusion of exon 6 in IL7R pre-mRNAs and respectively decreases or increases expression of the soluble isoform of IL7R (sIL7R). In certain embodiments, the oligonucleotide is an antisense oligonucleotide (ASO), or a splice-modulating antisense oligonucleotide (SM-ASO).
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