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Optically active segment for stereocontrolled oligonucleotide synthesis and its manufacturing method, and method for synthesizing sterically controlled oligonucleotide using the same
Optically active segment for stereocontrolled oligonucleotide synthesis and its manufacturing method, and method for synthesizing sterically controlled oligonucleotide using the same
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机译:用于立体控制寡核苷酸合成的光学活性段及其制造方法,以及使用该方法合成空间控制的寡核苷酸的方法
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摘要
An optically active segment for stereocontrolled oligonucleotide synthesis represented by the following formula (I), a method of producing the same, and a sterically controlled oligonucleotide synthesis method using the same.(in the expressionB is a protected / unprotected nucleoside base;R1 is a substituted / unsubstituted aliphatic group;R2R3The DMTR group or - P (R11) (nr12) 2;R11Och2ch2cnSch2ch2cn, etc.;R12 is a substituted / unsubstituted aliphatic or aromatic group;XHAlkylO-alkyl or the like;YHNHR 13Halogen or acylEther systemIs silyl based protecting hydroxyl groupForm an X-Y bond between X andN0 or 4 or less.)1
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