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OPTICALLY ACTIVE SEGMENT FOR STEREOCONTROLLED OLIGONUCLEOTIDE SYNTHESIS, PRODUCTION METHOD FOR SAME, AND STEREOCONTROLLED OLIGONUCLEOTIDE SYNTHESIS METHOD USING SAME
OPTICALLY ACTIVE SEGMENT FOR STEREOCONTROLLED OLIGONUCLEOTIDE SYNTHESIS, PRODUCTION METHOD FOR SAME, AND STEREOCONTROLLED OLIGONUCLEOTIDE SYNTHESIS METHOD USING SAME
Provided are: an optically active segment for stereocontrolled oligonucleotide synthesis represented by formula (I); a production method for the same; and a stereocontrolled oligonucleotide synthesis method using the same. (In the formula, B is a protected/unprotected nucleotide base; R1 is substituted/unsubstituted aliphatic group; R2 and R3 are a DMTr group or –P(R11)(NR12)2; R11 is OCH2CH2CN or SCH2CH2CN, for example; R12 is a substituted/unsubstituted aliphatic group or aromatic group; X is H, an alkyl, or an O-alkyl, for example; Y is H, NHR13, or a halogen, for example, or a hydroxyl group protected by an acyl, ether, or silyl protective group, or together with X forms a bond X-Y; and n is an integer of 0-4.)
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