LOCAL APPLICATION OF DIOXIDINE IN INFECTIOUS AND INFLAMMATORY DISEASES OF THE ORAL CAVITY

摘要

FIELD: pharmacology; medicine; chemical and pharmaceutical industry.;SUBSTANCE: invention relates to pharmacology, medicine and chemical and pharmaceutical industry, namely to a new local application of dioxidine (hydroxymethylquinoxalinedioxide) in the form of 0.001-0.4% wt./vol. of an aqueous solution with a pH of 3 to 7.5, where dioxidine acts as an agent, for the treatment and/or prevention of infectious and inflammatory diseases of the oral cavity and pharynx, such as stomatitis and gingivitis. The above-mentioned dioxidine solution can be used as a spray or liquid for rinsing or cleaning the oral cavity and pharynx, or in the form of drops. The use of such a dioxidine solution in the oral cavity is characterized by the absence of a side effect in the form of nausea and vomiting in case of accidental ingestion, which can be observed with the use of known dioxidine solutions (with a concentration of 0.5% and 1%). ;EFFECT: use of dioxidine in an aqueous solution with a concentration and pH in the above-mentioned ranges provides an increase in the photostability and resistance to self-oxidation of dioxidine in solution compared to known dioxidine solutions, an increase in the quality of dioxidine solutions and their safety due to the absence of microcrystals in them.;24 cl, 5 tbl, 6 ex