Disease resistant and Growth promoting Effect of Nvhuang Fuzheng Oral Liquid on Chicks and Its Enhancement Effect on Infectious Bursal Disease Virus (IBDV) Vaccine

摘要

[Objective] The paper was to investigate the clinical effects of Nvhuang Fuzheng oral liquid on immunity enhancement, disease resistance and growth promotion of chicks. [Method] In the test, 3 day old Daninghe chicks were divided into normal control group, Nvhuang Fuzheng oral liquid group and positive control group. Chicks were administrated with drugs for 7 d before immunization. After vaccination, chicks were observed for 4 weeks, to statistically count the incidence state of chicks. Effects of Nvhuang Fuzheng oral liquid on growth performance, serum immunoglobulin, cytokine and infectious bursal disease virus (IBDV) antibody were studied. [Result] Compared to normal control group, Nvhuang Fuzheng oral liquid significantly improved the weight of chicks and reduced the feed gain ratio (P<0.05); significantly reduced the morbidity and mortality and increased the survival rate of chicks (P<0.05); continuously increased IgG, IgM and IL 2 content significantly in the serum of chicks (P<0.05); extremely improved IFN γ content in the serum at 7 d post drug administration (P<0.01). After vaccination of IBDV vaccine for 1 and 2 weeks, Nvhuang Fuzheng oral liquid significantly improved IBDV antibody titer and positive rate of chicks compared to normal control group (P<0.05); at 3 weeks post immunization, the antibody positive rate reached 100%. [Conclusion]Nvhuang Fuzheng oral liquid improved immunoglobulin and cytokine levels of chicks, enhanced the immunity and reduced the occurrence of diseases (the morbidity was reduced by 15% and the mortality was reduced by 30%), enhanced disease resistant ability and promoted the growth of chicks. Meantime, it improved the immune effect of IBDV vaccine.